Peptide Receptor Radionuclide Therapy for NETs | OncLive

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Ga-68 labeled somatostatin analogues: •DOTATATE •DOTATOC •DOTANOC Bind to Somatostatin receptors (SSTR-2) on tumor cells. Main clinical use Neuroendocrine Tumors (NETs) •Pancreatic NET •Small bowel carcinoid •Lung NET •Unknown primary NET •Metastatic NET staging Sensitivity far higher than FDG in well-differentiated NETs. Why it works better than FDG in NETs •NETs are slow growing •Low glycolysis → FDG may be negative •But high SSTR expression → DOTA PET strongly positive FDG = aggressiveness DO