Merck & Co. will apply the somatic genomics platform Quotient Therapeutics to discover novel drug targets in inflammatory bowel disease (IBD), through a collaboration that could generate up to $2.2 ...

Two new studies from Karolinska Institutet in Sweden have investigated how mutations that occur in muscles and blood vessels over time can affect aging. The studies, which are published in Nature ...

Discussion of the potential of using pluripotent stem cells for tissue transplantation has raised issues about the frequency and types of spontaneous mutation in these cells. In the March 19 ...

Germ cell tumor (GCT) is one of the most common malignancies affecting young men. Approximately 30% of patients with metastatic disease experience disease progression following adequate first-line ...

Cancer is characterized by abnormal metabolic processes different from those of normal cells. Therefore, cancer metabolism has been extensively studied to develop effective diagnosis and treatment ...

Cardiovascular death had a strong tie to the somatic mutations that often accrue with aging in people with subclinical atherosclerosis, an observational study found. For asymptomatic people who had ...

High-sensitivity sequencing of recurrent, cell-type–specific variants aims to strengthen causal inference versus germline ...

August Weismann's germ plasm theory of the late 19th century posited that only germ cells, e.g., sperm and egg cells in ...

After generating interest from the likes of Pfizer and GSK, Quotient Therapeutics’ somatic genomics platform has attracted ...